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AM50445PU-N 2,2,7-Trimethylguanosine Antikörper

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Mouse anti Human, Mouse 2,2,7-Trimethylguanosine K121

Produktbeschreibung für 2,2,7-Trimethylguanosine

Mouse anti Human, Mouse 2,2,7-Trimethylguanosine K121.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation.

Produktdaten von 2,2,7-Trimethylguanosine

Produkt-Kategorie Primärantikörper
Menge 0.1 mg
Präsentation Purified
Reaktivität Hu, Ms
Anwendungen ICC/IF, IP
Klonalität Monoclonal
Klon K121
Wirt Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datenblatt-Auszug

Immunogen
Immunogen:
2,2,7-trimethylguanosine.
Isotype control AM03095PU-N, SM10P (for use in human samples)
Anwendung Immunoprecipitation: A representative lot from an independent laboratory was immunoprecipitated in IP (Moketi, S., et al. (2002). Mol Cell. 10(3):599-609.).
Immunocytochemistry: A 1/500 dilution of this antibody detected 2,2,7-trimethylguanosine in NIH/3T3, HeLa.and A431 cells.
Immunoaffinity Purification: A representative lot from an independent laboratory was used in IAP (Krainer, A.R., et al. (1988). Nucleic Acids Res. 16(20):9415-9429.).
Background The 2,2,7-trimethylguanosine cap structure is found on the 5’ end of small nuclear RNAs and small nucleolar RNAs. Initially, these RNA molecules are capped with 7-monomethylguanosine (m7G) which is then methylated by the trimethylguanosine synthase enzyme to form 2,2,7-trimethylguanosine. The synthesis of 2,2,7-trimethylguanosine occurs in the cytoplasm and is an important marker for nuclear localization of RNA molecules. Capping of RNAs is an important requirement for RNA transport and splicing processes. Uncapped RNAs are rapidly degraded by the 5′ exoribonuclease enzyme. 2,2,7-trimethylguanosine capping may play a role in the expression of viral RNAs.
Concentration lot-specific
Storage Store undiluted at 2-8°C. 
Shelf life: one year from despatch.
Format
Purification:
Protein G Chromatography
Buffer System:
0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
State:
Liquid purified Ig fraction
Purified
Specificity
Specificity:
Demonstrated to react with Human and Mouse.

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