AM31723PU-N Acid ceramidase (25-125) Antikörper

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50 µg / 475,00 €
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Mouse anti Human Acid ceramidase 1A7

AM31723PU-N

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Produktbeschreibung für Acid ceramidase

Mouse anti Human Acid ceramidase 1A7.
Properties: (25-125)
Presentation: Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Produktdaten von Acid ceramidase

Produkt-Kategorie Primärantikörper
Target-Kategorie
Menge 50 µg
Synonyme ASAH, ASAH1, Acylsphingosine deacylase, N-acylsphingosine amidohydrolase, PHP32, Putative 32 kDa heart protein
Präsentation Purified
Reaktivität Hu
Anwendungen E, P, WB
Klonalität Monoclonal
Klon 1A7
Wirt Mouse
Isotype IgG3
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
Q13510
Immunogen:
ASAH1 antibody was raised against ASAH1 (NP_808592, 25 a.a. ~ 125 a.a) partial recombinant protein with GST tag
GeneID:
427
Remarks:
MW of the GST tag alone is 26 KDa.
Eigenschaften 25-125
Isotype control AM03097PU-N
Anwendung ELISA.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 1/500 - 1/1000.
Background Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer's disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.
Concentration 0.27 mg/ml
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein A Chromatography
Buffer System:
PBS, pH 7.4
State:
Liquid purified Ig fraction
Purified
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
Recognizes Acid ceramidase ASAH1 at aa 25-125.
Gene ID 427

Accessory Products

Proteins and/or Positive Controls

Proteine zu Acid ceramidase (6 Produkte)

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Acid ceramidase (transcript variant 2)

Acid ceramidase Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / 748,00 €
  OriGene Technologies, Inc.

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  Abnova Taiwan Corp.

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Acid ceramidase Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

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Positive controls for Acid ceramidase (2 Produkte)

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Acid ceramidase Lysate (Non-Denatured)

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  Abnova Taiwan Corp.

ASAH1 Lysate

Western Blot: ASAH1 Lysate [NBL1-07747] - Western Blot experiments.  Left - Empty vector transfected control cell lysate (HEK293 cell lysate); Right - Over-expression Lysate for ASAH1. Protein
  Novus Biologicals Inc.
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