TA326464 AHA1 / AHSA1 Antikörper

Rat Monoclonal Anti-Aha2 Antibody

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0.1 mg / 426,00 €
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rat anti Human, Mouse, Rat AHA1 / AHSA1 25F2.D9

TA326464

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Produktbeschreibung für AHA1 / AHSA1

Rat anti Human, Mouse, Rat AHA1 / AHSA1 25F2.D9.
Presentation: Purified
Product is tested for Paraffin Sections, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Produktdaten von AHA1 / AHSA1

Produkt-Kategorie Primärantikörper
Target-Kategorie
Menge 0.1 mg
Synonyme Activator of 90 kDa heat shock protein ATPase homolog 1, C14orf3, HSPC322
Präsentation Purified
Reaktivität Hu, Ms, Rt
Anwendungen E, ICC/IF, IP, P, WB
Klonalität Monoclonal
Klon 25F2.D9
Wirt Rat
Isotype IgG2a
Shipping to Europe, USA/Canada
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies, Inc.

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
Q8BK64
Immunogen:
Mouse Aha1.
GeneID:
217737
Isotype control SM15P, SM15PX
Anwendung ELISA.
Western blot: 
1 μg/mL of this antibody was sufficient for detection of Aha1 in 10μg of rat tissue lysate by colorimetric immunoblot analysis using Goat anti-rat IgG:HRP as the secondary antibody.
Immunoprecipitation.
Immunofluorescence.
Immunocytochemistry.
Immunohistochemitry on Paraffin Sections:
5 µg/ml (heat-induced antigen retrieval is required).
Background Aha1 is a member of the Hsp90 cochaperone family, and is thought to stimulate Hsp90 ATPase activity by competing with p23 and other co-chaperones for Hsp90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/Hsp90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).
Concentration 1.2 mg/ml
General Readings
  1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub.
  2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796.
  3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723.
  4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein G Chromatography
Buffer System:
0.02M Potassium Phosphate, pH 7.2 containing 0.15M Sodium Chloride
State:
Liquid purified IgG fraction
Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse and Rat.
Specificity
Specificity:
This antibody detects ~38kDa, can run at up to 45kD on SDS-PAGE.
1 μg/ml of this antibody was sufficient for detection of Aha1 in 10 μg of Rat tissue lysate by colorimetric Immunoblot analysis using Goat anti-Rat IgG-HRP as the secondary antibody.

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