TA801287 CD246 / Anaplastic lymphoma kinase Antikörper

ALK mouse monoclonal antibody, clone OTI1A4 (formerly 1A4)

See related secondary antibodies

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0.1 ml / 379,00 €
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

TrueMAB

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Mouse anti Human CD246 / Anaplastic lymphoma kinase OTI1A4

TA801287

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Produktbeschreibung für CD246 / Anaplastic lymphoma kinase

Mouse anti Human CD246 / Anaplastic lymphoma kinase OTI1A4.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Produktdaten von CD246 / Anaplastic lymphoma kinase

Produkt-Kategorie Primärantikörper
Target-Kategorie
Menge 0.1 ml
Synonyme ALK tyrosine kinase receptor
Präsentation Purified
Reaktivität Hu
Anwendungen P, WB
Klonalität Monoclonal
Klon OTI1A4
Wirt Mouse
Isotype IgG2b
Shipping to Europe, USA/Canada
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies, Inc.

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
Q9UM73
Immunogen:
Human recombinant protein fragment corresponding to amino acids 1300-1620 of human ALK (NP_004295) produced in E.coli.
GeneID:
238
Isotype control AM03110PU-N, SM12P
Anwendung WB 1:2000
Background This gene encodes a receptor tyrosine kise, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kise domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including aplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011].
Product Citations
Originator or purchased from resellers:
  1. Wang Q, He Y, Yang X, Wang Y, Xiao H. Extraordinary response to crizotinib in a woman with squamous cell lung cancer after two courses of failed chemotherapy. BMC Pulm Med. 2014 May 15;14:83. doi: 10.1186/1471-2466-14-83. PubMed PMID: 24885608. (Free PMC Article available, 2 images available)
  2. Gruber K, Kohlhäufl M, Friedel G, Ott G, Kalla C. A novel, highly sensitive ALK antibody 1A4 facilitates effective screening for ALK rearrangements in lung adenocarcinomas by standard immunohistochemistry. J Thorac Oncol. 2015 Apr;10(4):713-6. doi: 10.1097/JTO.0000000000000427. PubMed PMID: 25789835.
  3. Collin M, Charles A, Barker A, Khosa J, Samnakay N. Inflammatory myofibroblastic tumour of the bladder in children: A review. J Pediatr Urol. 2015 Apr 20. pii: S1477-5131(15)00110-2. doi: 10.1016/j.jpurol.2015.03.009. PubMed PMID: 25982020.
Format
Purification:
Purified from mouse ascites fluids by affinity chromatography
Buffer System:
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteine zu CD246 / Anaplastic lymphoma kinase (17 Produkte)

Katalog-Nr. Spezies Präs. Reinheit   Source  

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / 788,00 €
  OriGene Technologies, Inc.

CD246 / Anaplastic lymphoma kinase (C-term DDK/His tag)

CD246 / Anaplastic lymphoma kinase Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / 748,00 €
  OriGene Technologies, Inc.

CD246 / Anaplastic lymphoma kinase (N-term polyhistidine tag)

CD246 / Anaplastic lymphoma kinase Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
SF9 cells
20 µg / 411,00 €
  OriGene Technologies, Inc.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human Purified E. coli
  OriGene Technologies GmbH

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human Purified E. coli
  OriGene Technologies GmbH

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human Purified E. coli
  OriGene Technologies GmbH

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human
  Abnova Taiwan Corp.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human
  Abnova Taiwan Corp.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human
  Abnova Taiwan Corp.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human
  Abnova Taiwan Corp.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human
  Abnova Taiwan Corp.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human
  Abnova Taiwan Corp.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human
  Abnova Taiwan Corp.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human
  Abnova Taiwan Corp.

CD246 / Anaplastic lymphoma kinase

CD246 / Anaplastic lymphoma kinase Human
  Abnova Taiwan Corp.
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