BP5074 Cytokeratin 7 Antikörper

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0.1 ml / 380,00 €
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Guinea Pig anti Human Cytokeratin 7


Produktbeschreibung für Cytokeratin 7

Guinea Pig anti Human Cytokeratin 7.
Presentation: Serum
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Paraffin Sections.

Produktdaten von Cytokeratin 7

Produkt-Kategorie Primärantikörper
Menge 0.1 ml
Synonyme CK-7, CK7, K-7, K7, KRT-7, KRT7, Keratin type II cytoskeletal 7, Keratin-7, SCL, Sarcolectin
Präsentation Serum
Reaktivität Hu
Anwendungen C, ICC/IF, P, WB
Klonalität Polyclonal
Wirt Guinea Pig
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)


Swiss Prot Num:
Synthetic peptide (C-SAGPGLLKAYSIRT) of human keratin K7 (formerly also designated cytokeratin 7), coupled to KLH.
Anwendung Western blotting: 1/3000 (ECL).
Immunohistochemistry on frozen Sections: 1/200.
Immunohistochemistry on paraffin-embedded: 1/100
(after microwave treatment).
Cytological material.
Incubation time: 1 h at RT; extended with paraffin sections.
Positive control: Glandular epithelia (e.g. sweat glands, sebaceous glands); Merkel cells.
Background Cytokeratin 7 is a 54kD intermediate filament protein found in a variety of glandularepithelia. Cytokeratin 7 has been found in columnar and glandular epithelium of the lung, cervix, breast, bile ducts and larger collecting ducts of the kidney. It is present in the transitional epithelium of bladder as well as ovarian and lungepithelia, and occasionally staining of blood vessel cell walls, particularly endothelial cells, may be observed. However, Cytokeratin 7 is not expressed by epithelial cells of the gastrointestinal tract, colon or prostate. Keratin 7 is often co expressed with keratin 19.
General Readings Moll, R., Franke, W.W., Schiller, D.L., Geiger, B. and Krepler, R.: The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells. Cell 31, 11-24 (1982).
Ramaekers, F., van Niekerk C., Poels, L., Schaafsma, E., Huijsmans, A., Robben, H., Schaart, G. and Vooijs, P.: Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas. Am. J. Pathol. 136, 641-655 (1990)
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
0.09% Sodium Azide
0.5% BSA
Stabilized antiserum
Reacts with basic keratin K7 (Mr 54 000).
Excellent marker for the discrimination of specific subtypes of adenocarcinoma: e.g. adenocarcinoma of pancreas, bile duct carcinoma and transitional carcinoma of bladder are stained, whereas hepatocellular and prostate carcinomas are negative.
Detects specific subtypes of adenocarcinomas: Adenocarcinoma of pancreas, gallbladder, lung, cervix; cholangio carcinoma of liver; ductal and lobular carcinoma of breast; carcinomas of ovary; transitional cell carcinoma of bladder; mesothelioma; negative with most cases of hepatocellular carcinoma. In colorectal carcinoma early stages are reported to be negative but advanced stages of tumor development are positive for keratin K7 expression.
Gene ID 3855
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Positive controls for Cytokeratin 7 (3 Produkte)

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Cytokeratin 7 Lysate

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Left-Control; Right -Over-expression Lysate for KRT7
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