SM1662 Huntingtin Antikörper

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0.1 mg / 410,00 €
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Mouse anti Human, Mouse, Rabbit Huntingtin HDC8A4

Produktbeschreibung für Huntingtin

Mouse anti Human, Mouse, Rabbit Huntingtin HDC8A4.
Presentation: Purified
Product is tested for Frozen Sections, Immunoprecipitation, Western blot / Immunoblot.

Produktdaten von Huntingtin

Produkt-Kategorie Primärantikörper
Target-Kategorie
Menge 0.1 mg
Synonyme HD, HTT, Huntington Disease Protein, IT15
Präsentation Purified
Reaktivität Hu, Ms, Rb
Anwendungen C, IP, WB
Klonalität Monoclonal
Klon HDC8A4
Wirt Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
P42858
Immunogen:
Recombinant protein corresponding to amino acids 2703 - 2911 of huntingtin
GeneID:
3064
Isotype control AM03095PU-N, SM10P (for use in human samples)
Anwendung Immunohistochemistry on frozen sections.
Immunoprecipitation.
Western blot.
Background Huntington's disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegeneative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years. The HD gene product is widely expressed in human tissues, with the highest level of expression in the brain. The huntingtin gene product is expressed at similar levels in patients and controls, which suggests that the expansion of the polyglutamine repeat induces a toxic gain of function perhaps through interactions with other cellular proteins. Using yeast two-hybrid system, HAP1 (huntingtin associated protein 1) has been identified, that associates with huntingtin protein. The In vitro data suggest that the association between HAP1 and huntingtin is enhanced by increasing length of glutamine repeat.
Concentration 1.0 mg/ml
General Readings
  1. Wilkinson FL, Nguyen TM, Manilal SB, Thomas P, Neal JW, Harper PS, et al. Localization of rabbit huntingtin using a new panel of monoclonal antibodies. Brain Res Mol Brain Res. 1999 May 21;69(1):10-20. PubMed PMID: 10350633.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography on Protein G
Buffer System:
PBS containing 0.09% Sodium Azide
State:
Liquid purified IgG
Purified
Specificity
Specificity:
This antibody reacts with an epitope corresponding to the HDC region (2703 - 2911 amino acids) of the huntingtin protein. Clone HDC8A4 detects a 350KD band on western blots but also detects smaller degradation products of huntingtin. Clone HDC8A4 recognises both denatured and native huntingtin in human brain. The combined use of clone HDC8A4 (SM1662), HDB4E10 (SM1661) and HDA3E10 (SM1660) demonstrate that huntingtin is enriched in neuronal cells in the brain.
Species:
Rabbit, Human, Mouse.
Gene ID 3064
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Accessory Products

Proteins and/or Positive Controls

Proteine zu Huntingtin (2 Produkte)

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Huntingtin

Huntingtin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
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Huntingtin

Huntingtin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
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Positive controls for Huntingtin (1 Produkte)

Katalog-Nr. Spezies Präs. Reinheit   Source  

HTT overexpression lysate

HTT overexpression lysate
0.1 mg / 495,00 €
  OriGene Technologies, Inc.
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