AP09163PU-N Interleukin-13 / IL13 Antikörper

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0.1 mg / 460,00 €
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Kurzübersicht

Rabbit anti Porcine Interleukin-13 / IL13

Produktbeschreibung für Interleukin-13 / IL13

Rabbit anti Porcine Interleukin-13 / IL13.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Produktdaten von Interleukin-13 / IL13

Produkt-Kategorie Primärantikörper
Target-Kategorie
Menge 0.1 mg
Synonyme IL-13, NC30
Präsentation Aff - Purified
Reaktivität Por
Anwendungen E, WB
Klonalität Polyclonal
Wirt Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
Q95J68
Immunogen:
Full length recombinant protein raised in yeast, corresponding to mature swine IL-13 protein
GeneID:
396721
Anwendung ELISA: 1/11,000.
Western Blot: 1.5 - 2 µg/ml.
Background Interleukin 13 (IL-13), of the IL-4 superfamily, is a cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, that is an important mediator of allergic inflammation and disease. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Ra) and at least one IL-13-specific binding chain. Most of the biological effects of IL-13, like those of IL-4, are linked to a single transcription factor, STAT6. In humans, IL-13 can induce immunoglobulin E (IgE) secretion from activated B cells. In mice, deletion of IL-13 does not markedly affect either Th2 cell development or antigen-specific IgE responses induced by potent allergens. Deletion of IL-4 abrogates these responses. IL-13 acts as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thus altering physiological function. Although IL-13 is associated primarily with the induction of airway disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, it also induces airway matrix metalloproteinases as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation.
Concentration 1.0 mg/mL by UV absorbance at 280 nm
General Readings
  1. Trigona WL, Brown WC, Estes DM. Functional implications for signaling via the IL4R/IL13R complex on bovine cells. Vet Immunol Immunopathol. 1999 Dec 15;72(1-2):73-9. PubMed PMID: 10614495.
  2. B.Lew, D.Lyles, K.Dempsey, Y.Zhao (2000) Mitogenic effect of IL-13 in bovine airway smooth muscle cells (ASMC). Journal of Allergy and Clinical Immunology, Volume 105, Issue 1, Page S299
Storage Prior to reconstitution store at 2-8°C.
Following reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography on Protein A
Buffer System:
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
State:
Lyophilized
Aff - Purified
Reconstitution:
Restore with 100 µL of deionized water or equivalent.
Species Reactivity
Species reactivity (expected):
Sheep, Dolphin, Beluga, Bovine, Human, Certain monkey, Dusky titi, Macaque, Baboon, Mangabey, Canine, Llama, Camel, Galago, Horse, Rat, Mouse, Gerbil.
Species reactivity (tested):
Porcine.
Specificity
Specificity:
This antibody reacts to Interleukin-13.
Gene ID 396721

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