DDX0334HRPO-100 Interleukin-17A (IL17A) Antikörper

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0.1 mg / 490,00 €
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Kurzübersicht

Mouse anti Canine, Human, Mouse Interleukin-17A (IL17A) 412G6.06

Produktbeschreibung für Interleukin-17A (IL17A)

Mouse anti Canine, Human, Mouse Interleukin-17A (IL17A) 412G6.06.
Presentation: HRP
Product is tested for Western blot / Immunoblot, ELISA (detection).

Produktdaten von Interleukin-17A (IL17A)

Produkt-Kategorie Primärantikörper
Target-Kategorie
Menge 0.1 mg
Synonyme CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17
Präsentation HRP
Reaktivität Can, Hu, Ms
Anwendungen E(detection), WB
Klonalität Monoclonal
Klon 412G6.06
Wirt Mouse
Isotype IgG1
Shipping to Germany, USA/Canada
PDF datasheet Datenblatt ansehen
Hersteller Dendritics SAS

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
Q16552
Immunogen:
rhCytotoxic T Lymphocyte associated-Antigen 8 transfected COS-7 cells.
GeneID:
3605
Anwendung DDX0334P-50 DDX0334P-100 Purified: ELISA capture, FACS intracellular, Neutralization, Western Blot. 
DDX0334B-50 DDX0334B-100 Biotin: ELISA Detection. Western Blot.
DDX0334HRPO-50 DDX0334HRPO-100 HRPO: ELISA Detection. Western Blot.

Usage recommendation:

*This monoclonal antibody may be used between 1-10 μg/ml.
*Optimal dilution should be determined by each laboratory for each application.
*Coupled antibody: to maintain RT before use.
Background IL-17 (cytotoxic T lymphocyte associated antigen 8) is a CD4+ T cell-derived cytokine that stimulates stromal cells and macrophages to secrete proinflammatory cytokines. To address a possible mechanism by which IL-17 may promote alloreactivity, we examined the influence of IL-17 on the differentiation and function of bone marrow-derived cells propagated in GM-CSF with or without IL-4 to promote dendritic cell (DC) growth. A minor proportion of CD11c+ DC expressed the IL-17R. IL-17 promoted the maturation of DC progenitors, as evidenced by increased cell surface expression of CD11c, costimulatory molecules (CD40, CD80, CD86), and MHC class II Ag, and allostimulatory capacity. IL-17 had a lesser effect on the phenotype and function of more fully differentiated myeloid DC. These findings suggest a role for IL-17 in allogeneic T cell proliferation that may be mediated in part via a maturation-inducing effect on DC. IL-17 appears to be a novel target for therapeutic intervention in allograft rejection. hIL17 stimulate epithelial, endothelial, and fibroblastic cells to secrete cytokines such as IL-6, IL-8, and G-CSF and PGE2. (Fossiez F et al, 1996 ; J. Exp. Med., 183:2593-2603 ; Fossiez F. et al, 1998 ; Int. Rev. Immunol., 16:541-551).
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C, et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med. 1996 Jun 1;183(6):2593-603. PubMed PMID: 8676080. (Free PMC Article available)
General Readings
  • Storage -20°C. KEEP CONTENTS STERILE: no preservative.
    Purified antibodies: avoid repeated freeze/thaw cycles. 
    Coupled antibodies: glycerol protects from freezing.
    Format
    Label:
    HRP
    Purification:
    QMA Hyper D ion exchange chromatography
    Buffer System:
    Purified: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8.
    Coupled: 100 μg in 200μl / 50 μg in 100 μl PBS 50% glycerol.
    Specificity
    Specificity:
    Human IL-17A. 
    Species cross-reactivity: Mouse, Dog.

    Accessory Products

    Proteins and/or Positive Controls

    Proteine zu Interleukin-17A (IL17A) (17 Produkte)

    Katalog-Nr. Spezies Präs. Reinheit   Source  

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human > 80 %
    Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
    Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
    HEK293 cells
    20 µg / 748,00 €
      OriGene Technologies, Inc.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human > 95 %
    Preparation: .
    Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
    E. coli
    10 µg / 299,00 €
      OriGene Technologies, Inc.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human > 95 %
    Preparation: .
    Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
    E. coli
    25 µg / 230,00 €
      OriGene Technologies, Inc.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human > 98 %
    Preparation: .
    Purity Detail: Purity is >98%, as determined by Coomassie stained SDS-PAGE.
    E. coli
    10 µg / 195,00 €
      OriGene Technologies, Inc.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human > 98 %
    Preparation: .
    Purity Detail: >98%, as determined by Coomassie stained SDS-PAGE.
    E. coli
    10 µg / 355,00 €
      OriGene Technologies, Inc.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human Purified ≥ 98 pure by SDS-PAGE and HPLC analyses. E. coli
      OriGene Technologies GmbH

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human Purified ≥ 98 pure by SDS-PAGE and HPLC analyses. E. coli
      OriGene Technologies GmbH

    Interleukin-17A (IL17A) (24-155, His-tag)

    Interleukin-17A (IL17A) Human Purified > 90 % by SDS - PAGE
    0.25 mg / 1.070,00 €
      OriGene Technologies GmbH

    Interleukin-17A (IL17A) (24-155, His-tag)

    Interleukin-17A (IL17A) Human Purified > 90 % by SDS - PAGE
    50 µg / 320,00 €
      OriGene Technologies GmbH

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
      Abnova Taiwan Corp.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
      Abnova Taiwan Corp.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human
      Abnova Taiwan Corp.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human
      Abnova Taiwan Corp.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human
      Abnova Taiwan Corp.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human
      Abnova Taiwan Corp.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human
      Abnova Taiwan Corp.

    Interleukin-17A (IL17A)

    Interleukin-17A (IL17A) Human Purified
      Novus Biologicals Inc.

    Positive controls for Interleukin-17A (IL17A) (2 Produkte)

    Katalog-Nr. Spezies Präs. Reinheit   Source  

    IL17A overexpression lysate

    IL17A overexpression lysate
    0.1 mg / 295,00 €
      OriGene Technologies, Inc.

    IL17 Lysate

    Western Blot: IL17 Lysate [NBL1-11912] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for IL17A
      Novus Biologicals Inc.
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