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NBP1-49615 Scn1a Antikörper

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Mouse anti Human, Mouse, Rat Scn1a S74-71

Produktbeschreibung für Scn1a

Mouse anti Human, Mouse, Rat Scn1a S74-71.
Presentation: Purified
Product is tested for Frozen Sections, Paraffin Sections, Immunoprecipitation, Western blot / Immunoblot.

Produktdaten von Scn1a

Produkt-Kategorie Primärantikörper
Menge 0.1 mg
Synonyme anti-FEB 3 antibody, anti-FEB3 antibody, anti-GEFSP 2 antibody, anti-GEFSP2 antibody, anti-NAC 1 antibody, anti-NAC1 antibody, anti-Nav 1.1 antibody, anti-Nav1.1 antibody, anti-SCN 1 antibody, anti-SCN1 antibody, anti-SCN2A1 antibody, anti-Scn 1a antibody, anti-Sodium channel protein brain I alpha subunit, anti-Sodium channel protein type I subunit alpha a, anti-Sodium channel voltage gated type I alpha ant, anti-Sodium channel voltage gated type I alpha sub, anti-Voltage gated sodium channel alpha 1 subunit, anti-sodium channel antibody, anti-voltage gated antibody
Präsentation Purified
Reaktivität Hu, Ms, Rt
Anwendungen C, IP, P, WB
Klonalität Monoclonal
Klon S74-71
Wirt Mouse
Isotype IgG1
Shipping to Europe only
PDF datasheet Datenblatt ansehen
Hersteller Novus Biologicals Inc.


Swiss Prot Num:
Fusion protein amino acids 1929-2009 (cytoplamsic Cterminus) of rat Nav1.1, accession number P04774.
Isotype control AM03095PU-N, SM10P (for use in human samples), SM20P (for use in rat samples)
Anwendung IHC-Fr, IF, P, IP, WB
Background Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Voltage gated sodium channels initiate action potentials in neurons. Nav1.1 is abundant in the adult brain, and primarily localized in cell bodies. Mutations in the Nav1.1 channels cause generalized epilepsy with febrile seizures plus (GEFS+). Studies show that Nav1.1 channels also play a crucial role in the excitability of cerebellar Purkinje neurons, with major contributions to peak, persistent and resurgent forms of sodium current and to sustained action potential firing (3).
Concentration 1 mg/ml
General Readings
  1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. 3. Kalume F., et al. (2007) J Neurosci. 27(41): 11065-11074.
Storage Store at -20C. Avoid freeze-thaw cycles.
Protein G purified
Buffer System:
In PBS pH7.4, 50% glycerol

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