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AM32902PU-N Siglec-H (50-100) Antikörper

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Kurzübersicht

Rat anti Mouse Siglec-H IMG23M15C8

Produktbeschreibung für Siglec-H

Rat anti Mouse Siglec-H IMG23M15C8.
Properties: (50-100)
Presentation: Purified
Product is tested for Paraffin Sections.

Produktdaten von Siglec-H

Produkt-Kategorie Primärantikörper
Menge 0.5 mg
Präsentation Purified
Reaktivität Ms
Anwendungen P
Klonalität Monoclonal
Klon IMG23M15C8
Wirt Rat
Isotype IgG2a
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
Q3Y597
Immunogen:
A portion of amino acids 50-100 of Mouse Siglec-H
Eigenschaften 50-100
Isotype control SM15P, SM15PX
Anwendung Immunohistochemistry on Paraffin Sections: 5 μg/ml.
Background Siglec-H, or sialic acid binding immunoglobulin-like lectin H, is a CD33 related protein expressed specifically by plasmacytoid dendritic cells or pDCs (1, 2).  Antigen-mediated delivery by Siglec-H in pDCs inhibits Th cell proliferation and further antibody responses.  This leads to lessened expansion and Th1/Th17 polarization (3).  Constant and low density antigen presentation by Siglec-H is thought to lead to an exhaustive type lessening of the response in CD4+ cells but not tolerance.  A number of pathways have been proposed for the Siglec-H induced T cell hyporesponsiveness.  Ever decreasing activation cycles in the presence of low level but continuous antigen delivery, as that observed with Siglec-H, have also been demonstrated to impart FoxP3+ Tregs immunosuppressive tolerogen-like effects (4, 5).  Ability to identify and control Siglec-H antigen mediated delivery activities with specific antibody provides a focal point for potential development of inflammation controls.
Concentration 0.5 mg/ml
General Readings
  1. http://www.copewithcytokines.de/cope.cgi?key=SIGLEC-H__REFERENCES
  2. Loschko, J et al. 2011 Antigen targeting to Plasmycotid Dendritic Cells via Siglec-H inhibits Th-Cell-Independent Autoimmunity. J. Immunol 187 doi: 10-4019/jimmunol. 11 02307.
  3. Zhang J, Raper A, Sugita N, Hingorani R, Salio M, Palmowski MJ, et al. Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Blood. 2006 May 1;107(9):3600-8. Epub 2006 Jan 5. PubMed PMID: 16397130.
  4. Apostolou I, von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J Exp Med. 2004 May 17;199(10):1401-8. PubMed PMID: 15148338. (Free PMC Article available, 5 images available)
  5. Kang HK, Liu M, Datta SK. Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells. J Immunol. 2007 Jun 15;178(12):7849-58. PubMed PMID: 17548623.
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
This products is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Format
Purification:
Protein G Chromatography
Buffer System:
PBS
Preservatives:
0.05% Sodium Azide
Stabilizers:
0.05% BSA
State:
Liquid purified IgG fraction
Purified
Specificity
Specificity:
This antibody recognizes Mouse Siglec-H.
Other species not tested.

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