TA319980 WDR35 (N-term) Antikörper

Rabbit Polyclonal WDR35 Antibody

See related secondary antibodies

Search for all "WDR35"

0.1 mg / 371,00 €
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Kurzübersicht

Rabbit anti Human WDR35

Produktbeschreibung für WDR35

Rabbit anti Human WDR35.
Properties: (N-term)
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Enzyme Immunoassay.

Produktdaten von WDR35

Produkt-Kategorie Primärantikörper
Target-Kategorie
Menge 0.1 mg
Synonyme IFT121, Intraflagellar transport protein 121 homolog, KIAA1336, WD repeat-containing protein 35
Präsentation Aff - Purified
Reaktivität Hu
Anwendungen E, P
Klonalität Polyclonal
Wirt Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies, Inc.

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
Q9P2L0
Immunogen:
16 amino acid synthetic peptide near the amino terminus of Human WDR35 (AP55454CP-N)
GeneID:
57539
Eigenschaften N-term
Add. information Blocking peptide available: AP55454CP-N
Anwendung

Immunohistochemistry on Paraffin Sections: 5 μg/ml.
Positive Control: Human testis.

Background WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.
Concentration 1.0 mg/ml
General Readings
  1. Gilissen C, Arts HH, Hoischen A, et al. Exome sequencing identifies WDR35 variants involded in Sensenbrenner syndrome. Am. J. Hum. Genet. 2010; 87:418-23.
  2. Mill P, Lockhart PJ, Fitzpatrick E, Mountford HS, Hall EA, Reijns MA, et al. Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis. Am J Hum Genet. 2011 Apr 8;88(4):508-15. doi: 10.1016/j.ajhg.2011.03.015. PubMed PMID: 21473986. (Free PMC Article available, 4 images available)
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
This antibody is specific to Human WDR35.
Species:
Human

Accessory Products

Proteins and/or Positive Controls

Positive controls for WDR35 (1 Produkte)

Katalog-Nr. Spezies Präs. Reinheit   Source  

WDR35 overexpression lysate

WDR35 overexpression lysate
0.1 mg / 295,00 €
  OriGene Technologies, Inc.
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