AP55797PU-N WWOX pTyr33 Antikörper

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0.1 mg / 300,00 €
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Rabbit anti Human, Mouse WWOX


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Produktbeschreibung für WWOX

Rabbit anti Human, Mouse WWOX.
Properties: pTyr33
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Produktdaten von WWOX

Produkt-Kategorie Primärantikörper
Menge 0.1 mg
Präsentation Aff - Purified
Reaktivität Hu, Ms
Anwendungen P, WB
Klonalität Polyclonal
Wirt Rabbit
Molecular weight 55 kDa
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)


Swiss Prot Num:
Peptide sequence around phosphorylation site of tyrosine 33 (W-V-Y(p)-Y-A) derived from Human WWOX (KLH-conjugated)
Eigenschaften pTyr33
Anwendung Western blot: 1:500~1:1000.
Immunohistochemistry on paraffin sections: 1:50~1:100.
Background WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism.
Concentration 1.0 mg/ml
General Readings
  1. Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res. 2000 Apr 15;60(8):2140-5. PubMed PMID: 10786676.
  2. Ried K, Finnis M, Hobson L, Mangelsdorf M, Dayan S, Nancarrow JK, et al. Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. Hum Mol Genet. 2000 Jul 1;9(11):1651-63. PubMed PMID: 10861292.
  3. Bednarek AK, Keck-Waggoner CL, Daniel RL, Laflin KJ, Bergsagel PL, Kiguchi K, et al. WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res. 2001 Nov 15;61(22):8068-73. PubMed PMID: 11719429.
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity chromatography using epitope-specific peptide
Buffer System:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse
The antibody detects endogenous levels of WWOX only when phosphorylated at tyrosine 33.

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