Antibodies to Calcium Sensing Receptor (CaSR) - FocusOn 077


The extracellular calcium (Ca(2+)(o))-sensing receptor (CaSR) enables the parathyroid glands and other CaSR-expressing cells involved in calcium homeostasis, such as the kidney and bone, to sense alterations in the level of Ca(2+)(o) and to respond with changes in function that are directed at normalizing the blood calcium concentration. Several disorders of Ca(2+)(o) sensing arise from inherited or acquired abnormalities that 'reset' the serum calcium concentration upwards or downwards.

Ca2+ acts as a first messenger via CaSR mediated activation of second messenger systems altering cellular physiology. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. It has been demonstrated that malignant transformations of cells are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Mutations in the human CaSR gene have been identified in several inherited disorders of Ca metabolism such as familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalcemia (ADH).

Antibody Panel to Calcium sensing Receptor (CaSR)

OriGene Technologies offers a panel of monoclonal and polyclonal antibodies for the detection of calcium sensing receptor in human, rat or mouse tissues. The antibodies can be used for Immunohistochemical methods, Paraffin sections, Immunocytochemistry as well as Western Blot.

Antibody Panel to Calcium sensing Receptor (CaSR)

Calcium sensing Receptor, CaSR antibody.


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Peters U, Chatterjee N, Yeager M, Chanock SJ, Schoen RE, McGlynn KA, Church TR, Weissfeld JL, Schatzkin A, Hayes RB. Association of genetic variants in the calcium sensing receptor with risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2004 Dec; 13(12): 2181-6.

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CaSR (N-term) Antikörper

Human Placenta (formalin-fixed, paraffin-embedded) stained with CASR antibody AP22631PU-N at 15 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Rt P, WB
0.25 ml / 425,00 €
  OriGene Technologies GmbH

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