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NB110-81560 Geldanamycin

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Produktdaten von Geldanamycin

Produkt-Kategorie Natural Compounds
Menge 1 mg
Synonyme Hsp90 inhibitor
Shipping to Not USA/Canada
PDF datasheet Datenblatt ansehen
Hersteller Novus Biologicals Inc.


Add. information Synthetic Geldanamycin-Biotin
98% pure
Soluble in DMSO
Purple solid
Anwendung , Synthetic Geldanamycin-Biotin 98% pure Soluble in DMSO Purple solid
Background Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1
General Readings
  1. Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8324-8. PubMed PMID: 8078881. (Free PMC Article available)
  2. Neckers L. (2002) Trends Mol. Med. 8: S55.
  3. Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, Simons JW, et al. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res. 2002 May 1;62(9):2478-82. PubMed PMID: 11980636.
  4. Clevenger RC, Raibel JM, Peck AM, Blagg BS. Biotinylated geldanamycin. J Org Chem. 2004 Jun 25;69(13):4375-80. PubMed PMID: 15202892.
Storage Store at -20C. Avoid freeze-thaw cycles.
Biotin- geldanamycin Compound
Not tested in other species.

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