SA6001XFD Alpha-Synuclein / SNCA (1-140)

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1 mg / 570,00 €
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Alpha-Synuclein / SNCA

SA6001XFD

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  • SA6001XFD

Produktbeschreibung für Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA.
Presentation: Purified

Produktdaten von Alpha-Synuclein / SNCA

Produkt-Kategorie Proteins & Growth Factors
Target-Kategorie
Menge 1 mg
Synonyme NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Präsentation Purified
Molecular weight 14.46 kDa
Source E. coli
Spezies (Protein) Human
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
P37840
Reinheit > 95 %
Background Alpha-Synuclein, an acidic neuronal protein, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha-Synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).
General Readings
  1. Jakes, R., et al. (1994) FEBS lett. 345, 27-32.
  2. Ueda, K., et al. (1993) Proc. Natl. Acad. Sci. USA 90, 11282-11286.
  3. Kim, J. (1997) Molecules and Cells 7, 78-83.
  4. Paik, S. R., et al. (1997) Arch. Biochem. Biophys. 344, 325-334.
Storage Upon receipt, store it immediately at 2-8°C for up to one month. For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch
Beschreibung
Description:
Purified human recombinant alpha-Synuclein (amino acids 1-140).
AA Sequence:
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Molecular weight:
(140 aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher).
Format
Buffer System:
20 mM Tris-HCl buffer (pH 7.5), 100 mM NaCl, 1mM MgCl2
Endotoxin level:
< 1.0 EU per 1 ug of protein (determined by LAL method)
Purity:
>95%
State:
Lyophilized from a 0.2 um filtered solution
Purified
Reconstitution:
Restore in sterile distilled water to a concentration of 1 mg/ml or less.
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