SA6002X Alpha-Synuclein / SNCA (A53T Mutant)

Search for all "Alpha-Synuclein / SNCA"

0.5 mg / 600,00 €
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Kurzübersicht

Alpha-Synuclein / SNCA

SA6002X

Mehr Bilder

  • SA6002X

Produktbeschreibung für Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA.
Presentation: Purified

Produktdaten von Alpha-Synuclein / SNCA

Produkt-Kategorie Proteins & Growth Factors
Target-Kategorie
Menge 0.5 mg
Synonyme NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Präsentation Purified
Molecular weight 14.490 kDa
Source E. coli
Spezies (Protein) Human
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
P37840
Reinheit > 95 % by SDS-PAGE
Background Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.
Concentration 1.0 mg/ml
General Readings
  1. Polymeropoulos M. H., et al.. (1997) Science 276, 2045- 2047.
  2. Park, S. M. et al. (2002) Blood, 100(7) 2506-2514.
Storage Store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Beschreibung
Description:
A Parkinson's disease-related point mutant (A53T) of alpha-Synuclein. A53T mutant of α-synuclein was overexpressed in E. coli and the recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.
AA Sequence:
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Molecular weight:
(140 aa) (Real MW on SDS-PAGE will be shift up)
Format
Buffer System:
20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl
Purity:
>95% by SDS-PAGE
State:
Liquid purified protein
Purified
  • LinkedIn