SA6005X Alpha-Synuclein / SNCA (NACP112)

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0.5 mg / 600,00 €
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Alpha-Synuclein / SNCA

SA6005X

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Produktbeschreibung für Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA.
Presentation: Purified

Produktdaten von Alpha-Synuclein / SNCA

Produkt-Kategorie Proteins & Growth Factors
Target-Kategorie
Menge 0.5 mg
Synonyme NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Präsentation Purified
Molecular weight 11.3 kDa
Source E. coli
Spezies (Protein) Human
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
P37840
Reinheit > 95 % by SDS-PAGE
Background Alpha-Synuclein, an acidic neuronal protein, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha-Synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).
Concentration 1.0 mg/ml (determined by BCA assay)
General Readings Park SM., et al. (2002) Blood. 100(7):2506-2514.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Beschreibung
Description:
An alternatively spliced (103-129) form of alpha-synuclein, alpha-Synuclein 112 was cloned into an E. coli expression vector by RT-PCR. The recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.
AA Sequence:
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKEGYQDYEP EA
Molecular weight:
(112 aa), confirmed by MALDI-TOF
Format
Buffer System:
20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl.
Purity:
>95% by SDS-PAGE
State:
Liquid purified protein
Purified
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