SA6010X Alpha-Synuclein / SNCA (1-95)

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0.5 mg / 600,00 €
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Alpha-Synuclein / SNCA

SA6010X

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  • SA6010X

Produktbeschreibung für Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA.
Presentation: Purified

Produktdaten von Alpha-Synuclein / SNCA

Produkt-Kategorie Proteins & Growth Factors
Target-Kategorie
Menge 0.5 mg
Synonyme NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Präsentation Purified
Molecular weight 9.391 kDa
Source E. coli
Spezies (Protein) Human
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
P37840
Reinheit > 95 % by SDS-PAGE
Background Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.
Concentration 1.0 mg/ml
General Readings
  1. Ueda et al., (1993) Proc. Natl. Acad. Sci. 90, 11282-11286.
  2. Jakes et al., (1994) FEBS Letters 345, 27-32.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Beschreibung
Description:
A deletion mutant of alpha-synuclein (amino acids 1-95), which contains the N-terminal amphipathic domain and NAC region.Alpha-synuclein 1-95 was overexpressed in E. coli and the recombinant protein was purified to apparent homogenity by using conventional column chromatography techniques.
AA Sequence:
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFV
Molecular weight:
(95 amino acids)
Format
Buffer System:
20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl
Purity:
>95% by SDS-PAGE
State:
Liquid protein
Purified
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