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AR10186PU-L PIK3CG (active kinase)

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Kurzübersicht

PIK3CG

AR10186PU-L

Produktbeschreibung für PIK3CG

PIK3CG.
Presentation: Purified

Produktdaten von PIK3CG

Produkt-Kategorie Proteins & Growth Factors
Target-Kategorie
Menge 10 µg
Synonyme 5-bisphosphate 3-kinase catalytic subunit gamma isoform, PI3-kinase subunit gamma, PI3K-gamma, Phosphatidylinositol-4, PtdIns-3-kinase subunit p110-gamma, p120-PI3K
Präsentation Purified
Source Insect cells
Spezies (Protein) Human
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
P48736
Reinheit > 95.0% as determined by SDS-PAGE
Background

PI3Kg is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3Kg-/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8a-DCs. In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3Kg.

Concentration 0.5 mg/ml
Storage

Store the antigen undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. 
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Beschreibung
Description:
Recombinant full length PI3Kg (126.3 kDa without Tag) carries an N-terminal His 8 affinity Tag.
Biological activity:
4.5 nmol/mg/min using Phosphatidylinositol as the substrate.
Format
Buffer System:
25mM HEPES, pH 8.0, 25mM NaCl, 2.5mM MgCl2 and 50% Glycerol
Purity:
> 95.0% as determined by SDS-PAGE
State:
Liquid sterile filtered clear solution
Purified
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