AR09983PU-N Sentan / SNTN (1-147, His-tag)

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0.1 mg / 300,00 €
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Sentan / SNTN

AR09983PU-N

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Produktbeschreibung für Sentan / SNTN

Sentan / SNTN.
Presentation: Purified

Produktdaten von Sentan / SNTN

Produkt-Kategorie Proteins & Growth Factors
Menge 0.1 mg
Synonyme S100 calcium-binding protein A1-like, S100-A1-like, S100A1L
Präsentation Purified
Molecular weight 18.6 kDa
Source E. coli
Spezies (Protein) Human
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
A6NMZ2
Reinheit > 90 %
Background SNTN, also known as Sentan, belongs to the S-100 family. SNTN is shown to localize exclusively to the bridging structure between the cell membrane and peripheral singlet microtubules, which specifically exists in the narrowed distal portion of cilia. Exogenously expressed sentan showed affinity for the membrane protrusions, and a protein-lipid binding assay revealed that sentan bound to phosphatidylserine. These findings suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport.
Concentration 0.5 mg/ml (determined by Bradford assay)
General Readings Muzny D.M., et al. (2006) Nature. 440:1194-1198.
Kubo A., et al. (2008) Mol. Biol. Cell 19:5338-5346.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Beschreibung
Description:
Recombinant human SNTN protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MGGCMHSTQD KSLHLEGDPN PSAAPTSTCA PRKMPKRISI SKQLASVKAL RKCSDLEKAI ATTALIFRNS SDSDGKLEKA IAKDLLQTQF RNFAEGQETK PKYREILSEL DEHTENKLDF EDFMILLLSI TVMSDLLQNI RNVKIMK
Molecular weight:
(167aa), confirmed by MALDI-TOF
Format
Buffer System:
20mM Tris-HCl buffer (pH 8.0) containing 50% glycerol, 0.15M NaCl, 1mM DTT
Purity:
>90%
State:
Liquid purified protein
Purified
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