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AR09487PU-N TIMP1

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Kurzübersicht

TIMP1

AR09487PU-N

Produktbeschreibung für TIMP1

TIMP1.

Produktdaten von TIMP1

Produkt-Kategorie Proteins & Growth Factors
Target-Kategorie
Menge 10 µg
Synonyme CLGI, EPA, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, Metalloproteinase inhibitor 1, TIMP, TIMP-1, Tissue inhibitor of metalloproteinases
Molecular weight 20.6 kDa
Source E. coli
Spezies (Protein) Human
Shipping to Worldwide
PDF datasheet Datenblatt ansehen
Hersteller Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datenblatt-Auszug

Immunogen
Swiss Prot Num:
P01033
Reinheit > 95 % pure by SDS-PAGE gel and HPLC analyses.
Add. information Centrifuge vial before opening.
Background TIMP1 is an extracellular inhibitor of MMPs (see above) including MMP1, 2, 3, 7, 8, 9, 10, 11, 12, 13, and 16. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP1 can also act through an MMP-independent mechanism to promote erythropoiesis by stimulating proliferation and differentiation of erythroid progenitors.
Storage Store the lyophilized protein at -20°C.
Following reconstitution product is stable for 3 months when stored in working aliquots with a carrier protein at -20°C.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Beschreibung
Description:
Recombinant Human TIMP-1 is a 20.6 kDa protein containing 184 amino acid residues.
AA Sequence:
CTCVPPHPQT AFCNSDLVIR AKFVGTPEVN QTTLYQRYEI KMTKMYKGFQ ALGDAADIRF VYTPAMESVC GYFHRSHNRS EEFLIAGKLQ DGLLHITTCS FVAPWNSLSL AQRRGFTKTY TVGCEECTVF PCLSIPCKLQ SGTHCLWTDQ LLQGSEKGFQ SRHLACLPRE PGLCTWQSLR SQIA
Biological activity:
TIMP1 activity was measured by its ability to inhibit Human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature.
Half maximal inhibition was obtained at a TIMP-1 concentration of approximately 0.5 µg/ml, when using an MMP-1 concentration of 1.6 µg/ml.
Molecular weight:
(184 aa)
Format
Endotoxin level:
< 0.1 ng per μg (1EU/μg)
Purity:
>95% pure by SDS-PAGE gel and HPLC analyses.
State:
Lyophilized purified protein.
Reconstitution:
Restore in water to a concentration of 0.1-1.0 mg/ml.
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