BBS4 antibody
Principal name
BBS4 antibody
Alternative names for BBS4 antibody
Bardet-Biedl syndrome 4 protein
Ncbi ID
9606, NP_149017.2, NM_033028, NP_149017, NP_780534.1, NM_175325
Available reactivities
Available hosts
Available applications
ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP)
Background of BBS4 antibody
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.













Primärantikörper
Katalog-Nr. | Wirt | Iso. | Klon | Präs. | Reakt. | Anwendungen | |
---|---|---|---|---|---|---|---|
TA344646 | BBS4 Antikörper |
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Rabbit Polyclonal Anti-BBS4 Antibody - middle region | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze | WB |
50 µg /
360,00 €
|
|
OriGene Technologies, Inc. | |||||||
TA344647 | BBS4 Antikörper |
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Rabbit Polyclonal Anti-BBS4 Antibody - N-terminal region | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze | WB |
50 µg /
360,00 €
|
|
OriGene Technologies, Inc. | |||||||
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