BUB3 antibody

Principal name

BUB3 antibody

Alternative names for BUB3 antibody

Mitotic checkpoint protein BUB3

SwissProt ID

O43684 (Human), Q1JQB2 (Bovin), Q9WVA3 (Mouse)

Gene ID

9184 (BUB3)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Chk (Chicken), Rt (Rat), African clawed frog, Mky (Monkey), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of BUB3 antibody

The mitotic checkpoint protein Bub3 is involved with the essential spindle checkpoint pathway which operates during early embryogenesis. Bub3 is important during G2 and early mitosis stages, permitting entry into mitosis depending upon the assembly state of microtubules, thus preventing premature sister chromatid separation, mis-segregation and aneuploidy. Bub3 contains four WD repeat domains and is required for the kinetochore localization of Bub1, a related kinase that is necessary for spindle assembly checkpoint function. Bub1 is able to autophosphorylate and can catalyze the phosphorylation of Bub3. Both Bub1 and Bub3 are mutually dependent for function. Altered Bub expression levels may significantly impair mitotic checkpoint function and is associated with tumor cell proliferation.

General readings

Loqarinho. E., et al. (2008) Mol Biol Cell 19(4): 1798-1813Warren. C.D., et al. (2002) Mol Biol Cell 13(9): 3029-3041Taylor. S.S., et al. (1998) J Cell Biol 142(1): 1-11

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Proteins & Growth Factors

Katalog-Nr. Spezies Präs. Reinheit Source  

BUB3 (transcript variant 2)

  Recombinant protein of human budding uninhibited by benzimidazoles 3 homolog (yeast) (BUB3), transcript variant 2  
BUB3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / 748,00 €
  OriGene Technologies, Inc.

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