CNTFR antibody

Principal name

CNTFR antibody

Alternative names for CNTFR antibody

CNTFR, Ciliary neurotrophic factor receptor alpha, CNTFR alpha

SwissProt ID

O88507 (Mouse), P26992 (Human), P51641 (Chick), Q08406 (Rat), Q71DR4 (Canfa)

Gene ID

1271 (CNTFR), 313173 (Cntfr), 12804

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CNTFR antibody

CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily. It was initially purified from the chick eye on the basis of its ability to promote survival of E8 chick ciliary ganglion neurons in culture. CNTF is synthesized by glia both in the CNS and PNS3 and it has been demonstrated that CNTF is ubiquitously distributed in neurons and glia throughout the rodent brain. CNTF effects are mediated by a tripartite receptor complex consisting of two sigl-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFRa).CNTFRa is anchored to the membrane by a glycosyl-phosphatidylinositol (GPI) linkage and lacks the intracellular sigling moiety. It can be cleaved from the GPI anchor to yield a soluble form of the receptor (sCNTFRa).CNTF binds to CNTFRa, the latter associates with gp130 which recruits LIFR. This leads to the activation of a sigling cascade involving the JAK/STAT pathway.CNTFRa knockout mice die within 24 hours after birth as opposed to CNTF knock animals which are viable. This strongly suggest that CNTFRa has other ligands besides CNTF. Indeed, CLC/CLF complex (cardiotrophin like cytokine/cytokine-like factor-1) binds CNTFRa and activates a similar sigling pathway to that of CNTF.

General readings

Yokota H, Yoshikawa M, Hirabayashi H, Nakase H, Uranishi R, Nishimura F, Sugie Y, Ishizaka S, Sakaki T.
Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFRalpha) following experimental intracerebral hemorrhage in rats.
Neurosci Lett. 2005 Apr 4;377(3):170-5. Epub 2005 Jan 4.
PMID: 15755520

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CNTFR Antikörper

  Rabbit Polyclonal Anti-CNTFR Antibody  
CNTFR Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
0.1 ml / 360,00 €
  OriGene Technologies, Inc.

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