DLG4 / PSD95 antibody

Principal name

DLG4 / PSD95 antibody

Alternative names for DLG4 / PSD95 antibody

DLGH4, PSD-95, Disks large homolog 4, SAP90, SAP-90, Postsynaptic density protein 95, Synapse-associated protein 90

SwissProt ID

P31016 (Rat), P78352 (Human), Q62108 (Mouse)

Gene ID

1742 (DLG4), 13385 (Dlg4), 29495

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Can (Canine), Ze (Zebrafish), Xen (Xenopus)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Immunoelectron Microscopy (EM), Paraffin Sections (P), Flow Cytometry (F)

Background of DLG4 / PSD95 antibody

Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an Nterminal variable segment followed by three aminoterminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain.
The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4).
PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).

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Primärantikörper

Katalog-Nr. Wirt Iso. Klon Präs. Reakt. Anwendungen  

DLG4 / PSD95 Antikörper

  Mouse Monoclonal Anti-PSD95 Antibody  
Western blot analysis of PSD95 in rat membrane using a 1:1000 dilution of the antibody Mouse IgG2a 6G6 Purified Bov, Hu, Ms, Rt C, F, WB
0.1 mg / 386,00 €
  OriGene Technologies, Inc.

DLG4 / PSD95 Antikörper

  Mouse Monoclonal Anti-PSD95 Antibody  
Western blot analysis of PSD95 in rat membrane using a 1:1000 dilution of the antibody Mouse IgG2a 7E3 Purified Bov, Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / 386,00 €
  OriGene Technologies, Inc.

DLG4 / PSD95 Antikörper

DLG4 / PSD95 Mouse IgG2a 6G6 Purified Bov, Hu, Ms, Rt C, ICC/IF, WB
25 µg / 220,00 €
  OriGene Technologies GmbH

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