IL18BP antibody

Principal name

IL18BP antibody

Alternative names for IL18BP antibody

Interleukin-18-binding protein, IL-18BP, Tadekinig-alfa

SwissProt ID

O95998 (Human), Q9Z0M9 (Mouse)

Gene ID

16068 (Il18bp), 10068 (IL18BP)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of IL18BP antibody

IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells.
This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.
IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions.

General readings

Shimizu,C., et al. (2012) Mod Rheumatol 22 (1), 73-79Fujita,T.,et al. (2011) Diabetes Res. Clin. Pract. 92 (3), E66-E69

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OmniKine™ Human IL-18 BPa ELISA Kit

OmniKine™ Human IL-18 BPa ELISA Kit  
96 Tests / 440,00 €
  Assay Biotech

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