Neuregulin 1 antibody

Principal name

Neuregulin 1 antibody

Alternative names for Neuregulin 1 antibody

NRG1, GGF, HGL, HRGA, NDF, SMDF, Heregulin, HRG, Breast cancer cell differentiation factor p45, Glial growth factor, Neu differentiation factor, Pro-neuregulin-1 membrane-bound isoform, Acetylcholine receptor-inducing activity, Sensory and motor neuron-derived factor

SwissProt ID

O93383 (Xenla), P43322 (Rat), Q02297 (Human), Q05199 (Chick), Q9UPE3 (Human)

Gene ID

3084 (NRG1), 112400 (Nrg1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Rb (Rabbit), Mky (Monkey), Eq (Equine), Por (Porcine), Sh (Sheep), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP)

Background of Neuregulin 1 antibody

Neuregulin 1 (NRG1) interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.

General readings

1. Choi W  et al. The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin. J Cell Sci 123:3102-11 (2010). IHC-Fr, WB ; Human . PubMed: 20736300

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CRISPR

Katalog-Nr. Spezies Donor Vector  

NRG1 - human gene knockout kit via CRISPR

NRG1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / 1.290,00 €
  OriGene Technologies, Inc.

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