UBE2L3 / UBCH7 antibody
Principal name
UBE2L3 / UBCH7 antibody
Alternative names for UBE2L3 / UBCH7 antibody
Ubiquitin-protein ligase L3, Ubiquitin carrier protein L3, E2-F1, L-UBC, UBCE7, Ubiquitin-conjugating enzyme E2 L3
Gene ID
7332 (UBE2L3)
Ncbi ID
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of UBE2L3 / UBCH7 antibody
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2L3 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro.This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
General readings
Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M. Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. J Biol Chem. 1996 Feb 2;271(5):2795-800. PMID: 8576257
















- Schnellfilter:
- Zitierungen (1)
- Stark validiert (1)
Primärantikörper
Katalog-Nr. | Wirt | Iso. | Klon | Präs. | Reakt. | Anwendungen | |
---|---|---|---|---|---|---|---|
TA308758 | UBE2L3 / UBCH7 Antikörper |
||||||
Rabbit Polyclonal antibody to UBE2L3 (ubiquitin-conjugating enzyme E2L 3) | |||||||
![]() |
Rabbit | IgG | Aff - Purified | Hu, Ms | ICC/IF, P, WB |
0.1 ml /
415,00 €
|
|
OriGene Technologies, Inc. | |||||||
![]() |
Highly validated antibody! |
||||||
TA302697 | UBE2L3 / UBCH7 (C-term) Antikörper |
||||||
Goat Polyclonal Antibody against UBE2L3 | |||||||
![]() |
Goat | Aff - Purified | Bov, Hu, Ms, Por, Rt | E, WB |
0.1 mg /
360,00 €
|
||
OriGene Technologies, Inc. | |||||||
AP11976PU-N | UBE2L3 / UBCH7 (N-term) Antikörper |
||||||
![]() |
Rabbit | Ig | Purified | Hu | P, WB |
0.4 ml /
415,00 €
|
|
OriGene Technologies GmbH | |||||||
![]() |
Proteins & Growth Factors
Katalog-Nr. | Spezies | Präs. | Reinheit | Source | |
---|---|---|---|---|---|
TP308780 | UBE2L3 / UBCH7 (transcript variant 1) |
||||
Recombinant protein of human ubiquitin-conjugating enzyme E2L 3 (UBE2L3), transcript variant 1 | |||||
![]() |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
748,00 €
|
|
OriGene Technologies, Inc. | |||||
Published recently! |